Термин, обозначающий компьютерное моделирование (симуляцию) эксперимента, чаще биологического. Фраза была создана по аналогии с фразами in vivo (в живом организме) и in vitro (в пробирке).
YouTube. The virtual human project (posted March 12, 2018). https://www.youtube.com/watch?v=1ZrAaDsfBYY.
Grieves, M. & Vickers, J. Digital twin: Mitigating unpredictable, undesirable emergent behavior in complex systems. In Transdisciplinary Perspectives on Complex Systems (eds. Kahlen, J., Flumerfelt, S. & Alves, A.), 85–113 (Springer, 2017).
Shafto, M. et al. DRAFT Modeling, Simulation, Information Technology & Processing Roadmap, Technology Area 11 (NASA, 2010).
Negri, E., Fumagalli, L. & Macchi, M. A review of the roles of digital twin in CPS-based production systems. Procedia Manuf. 11, 939–948 (2017).
Niederer, S. A., Sacks, M. S., Girolami, M. & Willcox, K. Scaling digital twins from the artisanal to the industrial. Nat. Comput. Sci. 1, 313–320 (2021).
El Saddik, A. Digital twins: The convergence of multimedia technologies. IEEE Multimed.(2018). https://doi.org/10.1109/MMUL.2018.023121167.
Лерой Худ, интервью с Питером Ковени и Роджером Хайфилдом, 12 августа 2021 г.
Тим Палмер, электронное письмо Питеру Ковени, 2 июня 2021 г.
Bauer, P., Thorpe, A. & Brunet, G. The quiet revolution of numerical weather prediction. Nature 525, 47–55 (2015).
Abbe, C. The needs of meteorology. Science 1(7), 181–182 (1895).
Alley, R. B., Emanuel, K. A. & Zhang, F. Advances in weather prediction. Science 363, 342–344 (2019).
European Commission. Shaping Europe’s digital future: Destination Earth. https:// digital-strategy.ec.europa.eu/en/policies/destination-earth (accessed May 29, 2022).
Mitchell, H. H., Hamilton, T. S., Steggerda, F. R. & Bean, H. W. The chemical composition of the adult human body and its bearing on the biochemistry of growth. J. Biol. Chem. 158, 625–637 (1945).
Proctor, J., Hsiang, S., Burney, J., Burke, M. & Schlenker, W. Estimating global agricultural effects of geoengineering using volcanic eruptions. Nature (2018). https://doi.org/10.1038/s41586-018-0417-3.
Dallas, V. & Vassilicos, J. C. Rapid growth of cloud droplets by turbulence. Phys. Rev. E— Stat. Nonlinear, Soft Matter Phys. (2011). https://doi.org/10.1103/PhysRevE.84.046315.
Morton, O. The Planet Remade: How Geoengineering Could Change the World (Granta, 2015).
Auffray, C. & Noble, D. Origins of systems biology in William Harvey’s masterpiece on the movement of the heart and the blood in animals. Int. J. Mol. Sci. (2009). https://doi.org/10.3390/ijms10041658.
Noble, D. Claude Bernard, the first systems biologist, and the future of physiology. Exp. Physiol. (2008). https://doi.org/10.1113/expphysiol.2007.038695.
Nosil, P. et al. Natural selection and the predictability of evolution in Timema stick insects. Science (2018). https://doi.org/10.1126/science.aap9125.
Пол Нерс, интервью с Питером Ковени и Роджером Хайфилдом, 25 сентября 2021 г.
Nurse, P. Biology must generate ideas as well as data. Nature 597, 305 (2021).
Charlton, W. Greek philosophy and the concept of an academic discipline. Hist. Polit. Thought 6, 47–61 (1985).
Coveney, P. & Highfield, R. The Arrow of Time: A Voyage through Science to Solve Time’s Greatest Mystery (W. H. Allen, 1991).
Coveney, P. & Highfield, R. Frontiers of Complexity: The Search for Order in a Chaotic World (Faber, 1996).
Hunter, P., Robbins, P. & Noble, D. The IUPS human physiome project. Pflugers Archiv Eur. J. Physiol. (2002). https://doi.org/10.1007/s00424-002-0890-1.
Hernandez-Boussard, T. et al. Digital twins for predictive oncology will be a paradigm shift for precision cancer care. Nat. Med. 27, 2065–2066 (2021).
Hunter, P. et al. A vision and strategy for the virtual physiological human in 2010 and beyond. Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. (2010). https://doi.org/10.1098/rsta.2010.0048.
Human Brain Project. The Human Brain Project: A Report to the European Commission. HBP-PS Consortium (2012).
Kitano, H. Grand challenges in systems physiology. Front. Physiol. 1, 3 (2010).
Хорхе Луис Борхес. Создатель (рассказы, стихотворения, интервью) / Пер. Б. В. Дубина. М.: Азбука-Аттикус, 2022.
Borges, J. L. On exactitude in science. Los Anales de Buenos Aires 1, 3 (March 1946).
Matzeu, G. et al. Large-scale patterning of reactive surfaces for wearable and environmentally deployable sensors. Adv. Mater. 32, 2001258 (2020).
Coveney, P. V, Groen, D. & Hoekstra, A. G. Reliability and reproducibility in computational science: Implementing validation, verification and uncertainty quantification in silico. Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 379, 20200409 (2021).
Bianconi, E. et al. An estimation of the number of cells in the human body. Ann. Hum. Biol. (2013). https://doi.org/10.3109/03014460.2013.807878.
Chellan, P. & Sadler, P. J. The elements of life and medicines. Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. (2015). https://doi.org/10.1098/rsta.2014.0182.
Питер Слоот, электронное письмо Питеру Ковени и Роджеру Хайфилду, 4 августа 2021 г.
Пол Нерс, интервью с Питером Ковени и Роджером Хайфилдом, 24 сентября 2021 г.
Succi, S. Sailing the Ocean of Complexity: Lessons from the Physics-Biology Frontier (Oxford University Press, 2022).
Nowak, M. A. & Highfield, R. Supercooperators: Altruism, Evolution, and Why We Need Each Other to Succeed (Canongate, 2011).
Toker, D., Sommer, F. T. & D’Esposito, M. A simple method for detecting chaos in nature. Commun. Biol. (2020). https://doi.org10.1038/s42003-019-0715-9.
Brenner, S. Life sentences: Detective Rummage investigates. Genome Biol. (2002). https://doi.org/10.1186/gb-2002-3-9-comment1013.
Yip, K. M., Fischer, N., Paknia, E., Chari, A. & Stark, H. Breaking the next cryo-EM resolution barrier—atomic resolution determination of proteins! bioRxiv (2020). https://doi.org/10.1101/2020.05.21.106740.
Venter, J. C. Life at the Speed of Light: From the Double Helix to the Dawn of Digital Life (Viking, 2013).
Bentley, D. R. et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 456, 53–59 (2008).
Branton, D. et al. The potential and challenges of nanopore sequencing. Nat. Biotechnol. 26(10),1146–1153 (2008).
Nurk, S. et al. The complete sequence of a human genome. bioRxiv (2021). https://doi.org/10.1101/2021.05.26.445798.
Nurse, P. What Is Life?: Five Great Ideas in Biology. (Scribe, 2020).
Venter, C., interview with Peter Coveney and Roger Highfield, December 29, 2021.
Levy, S. et al. The diploid genome sequence of an individual human. PLoS Biol. 5, 2113–2144 (2007).
Venter, J. C. A Life Decoded: My Genome, My Life (Viking, 2007).
Highfield, R. What’s wrong with Craig Venter? Mosaic (2016). https://mosaicscience.com/story/craig-venter-genomics-personalised-medicine/.
Perkins, B. A. et al. Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proc. Natl. Acad. Sci. U. S. A. 115, 3686–3691 (2018).
Крейг Вентер, интервью с Питером Ковени и Роджером Хайфилдом, 29 декабря 2021 г.
Gates, A. J., Gysi, D. M., Kellis, M. & Barabási, A.-L. A wealth of discovery built on the Human Genome Project—by the numbers. Nature 590, 212–215 (2021).
Munro, S., Freeman, M., Rocha, J., Jayaram, S. A., Stevens, T., et al. Functional unknomics: closing the knowledge gap to accelerate biomedical research. Preprint. https://www.biorxiv.org/content/10.1101/2022.06.28.497983v1.
Abascal, F. et al. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature (2020). https://doi.org/10.1038/s41586-020-2493-4.
Quinodoz, S. A. et al. Higher-order inter-chromosomal hubs shape 3D genome organization in the nucleus. Cell 174, 744–757.e24 (2018).
Sey, N.Y.A. et al. A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Nat. Neurosci. (2020). https://doi.org/10.1038/s41593-020-0603-0.
Herder, C. & Roden, M. Genetics of type 2 diabetes: Pathophysiologic and clinical relevance. Eur. J. Clin. Invest. 41, 679–692 (2011).
Ponomarenko, E. A. et al. The size of the human proteome: The width and depth. Int. J. Analyt. Chem. (2016). https://doi.org/10.1155/2016/7436849.
Venter, J. C. Life at the Speed of Light: From the Double Helix to the Dawn of Digital Life (Viking, 2013).